Respiratory Care 2010 vol. 55 (2) pp. 162-74
Thus, the currently recommended strategy of setting

PEEP without regard to transpulmonary pressure is predicted to benefit some patients while

harming others. Recently the use of esophageal manometry to identify the optimal ventilator

settings, avoiding both under-inflation and over-inflation, was proposed. This method shows promise

but awaits larger clinical trials to assess its impact on clinical outcomes…..

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