Abstract

 

filling

Background:  Chronic obstructive pulmonary disease (COPD) and heart failure with preserved ejection fraction overlap clinically, and impaired left ventricular (LV) filling is commonly reported in COPD. The mechanism underlying these observations is uncertain, but may include upstream pulmonary dysfunction causing low LV preload or intrinsic LV dysfunction causing high LV preload. The objective of this study is to determine if COPD and emphysema are associated with reduced pulmonary vein dimensions suggestive of low LV preload.

Methods:  The population-based MESA COPD Study recruited smokers aged 50-79 years who were free of clinical cardiovascular disease. COPD was defined by spirometry. Percent emphysema was defined as regions <-910 Hounsfield units on full-lung computed tomography. Ostial pulmonary vein cross-sectional area was measured by contrast-enhanced cardiac magnetic resonance and expressed as the sum of all pulmonary vein areas. Linear regression was used to adjust for age, gender, race-ethnicity, body size and smoking.

Results:  Among 165 participants, total pulmonary vein area was 558±159mm2 in COPD and 623±145mm2 in controls. Total pulmonary vein area was smaller in COPD (-57mm2 95%CI -106 to -7mm2; p=0.03) and inversely associated with percent emphysema (p<0.001) in fully adjusted models. Significant decrements in total pulmonary vein area were observed among participants with COPD alone, COPD with emphysema on computed tomography, and emphysema without spirometrically defined COPD.

Conclusions:  Pulmonary vein dimensions were reduced in COPD and emphysema. These findings support a mechanism of upstream pulmonary causes of under-filling of the LV in COPD and in patients with emphysema on computed tomography.

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