Thank you to:
Babak Sarani, MD
Assistant Professor of Surgery
Co-Director of the Rapid Response Team
Division of Traumatology and Surgical Critical Care
University of Pennsylvania

Despite advances in ventilator management, 31% to 38% of patients with adult respiratory distress syn- drome (ARDS) will die, some from progressive respira- tory failure. Inability to adequately oxygenate patients with severe ARDS has prompted extensive efforts to identify what are now known as alternative modes of ventilation including high-frequency oscillatory venti- lation and airway pressure release ventilation. Both modalities are based on the principles of the open-lung concept and aim to improve oxygenation by keeping the lung uniformly inflated for an extended period of time.

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