• In esophageal-pressure guided group, mechanical ventilation settings
determined by initial esophageal pressure measurements.
• Tidal volume set at 6ml per kg predicted body weight.
• PEEP set to achieve a transpulmonary pressure of 0-10cm H2O at end
expiration, according to a sliding scale based on PaO2 and FiO2 – see
• Also limited tidal volume to keep transpulmonary pressure <25cmH2O at
end-inspiration (limit rarely approached during study and tidal volume was
never reduced for this purpose)……..