“We have demonstrated for the first time that the extracellular matrix (ECM) produced by fibroblasts following stimulation with cigarette smoke extract is functionally different than non-exposed ECM, and that the cigarette smoke itself may prime the airways in such a way to create an environment whereby airway remodeling is encouraged,” wrote lead researcher David Krimmer, a PhD student who is working with senior investigator Dr. Brian Oliver at the Woolcock Institute of Medical Research, of the University of Sydney in Australia.

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